Status and Prospect of Comprehensive Treatment for Pancreatic Cancer with Oligometastatic Disease

Abstract

Oligometastatic disease indicates a distinct state in cancer patients characterized by a low metastatic burden of the cancer. With recent progress in the concept and strategy of comprehensive treatment of pancreatic cancer, there have been an increasing number of reports on successful conversion therapy for oligmetastatic pancreatic cancer. However, there is still a lack of high-quality clinical trials to prove the significance of surgical treatment for metastatic pancreatic cancer, and controversies exist on this topic. In this review, we summarize current status of pancreatic cancer oligometastasis, discuss the significance of conversion therapy strategies and the indications for surgical resection, and propose the future prospects in the field.