Update on transcription phenotypes in pancreatic cancer

Tumor subtypes of PC

Abstract

Compelling evidence demonstrates that pancreatic cancer (PC) was characterized by inter-patient and intra-tumor heterogeneity, which prompted us to establish a clinically applicable molecular taxonomy. The established tumor subtypes based on transcription profiles in PC have the potential to indicate the prognosis of patients and new therapeutic vulnerability. However, the current tumor phenotyping remains nascent and does not inform clinical management. This review summarizes the current tumor subtypes of PC, their potential clinical relevance, and underlying driving force. We also clarify the relationship between tumor subtypes defined by different studies.